Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

Li Yang; Yu-Bo Zhang; Ling Zhuang; Tao Li; Neng-Hua Chen; Zhong-Nan Wu; Pan Li; Yao-Lan Li; Guo-Cai Wang

doi:10.1055/s-0042-107252

Planta Medica, Table of Contents

Planta Med 2017; 83(01/02): 111-116
DOI: 10.1055/s-0042-107252

Natural Product Chemistry and Analytical Studies

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

Authors

Li Yang

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Yu-Bo Zhang

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Ling Zhuang

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Tao Li

²School of Biomedical Sciences, The University of Hong Kong, Central and Western District, Hong Kong
Neng-Hua Chen

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Zhong-Nan Wu

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Pan Li

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Yao-Lan Li

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
Guo-Cai Wang

¹Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

Abstract

Five new diterpenoid alkaloids, ajacisines A–E (1–5), were isolated from Delphinium ajacis, along with seven known alkaloids (6–12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds 1–12 were identified. All isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus, and compounds 3–5 and 8 exhibited moderate to weak effects with IC₅₀ values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 µM, respectively.

Key words

Delphinium ajacis - Ranunculaceae - diterpenoid alkaloid - anti-RSV activity

Full Text

References

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Supplementary Material

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